A fast responsive, highly selective and light-up fluorescent probe for the two-photon imaging of carboxylesterase in living cells

Author:

Wang Jianguo1234ORCID,Chen Qingqing1234,Tian Na56784,Zhu Wenping1234,Zou Hang910111213,Wang Xuesong56784ORCID,Li Xiaokang1234ORCID,Fan Xiaolin1234,Jiang Guoyu1234ORCID,Tang Ben Zhong910111213

Affiliation:

1. Key Laboratory of Organo-Pharmaceutical Chemistry

2. Gannan Normal University

3. Ganzhou 341000

4. P. R. China

5. Key Laboratory of Photochemical Conversion and Optoelectronic Materials

6. Technical Institute of Physics and Chemistry

7. Chinese Academy of Sciences

8. Beijing 100190

9. Department of Chemistry

10. Institute for Advanced Study

11. Institute of Molecular Functional Materials, and State Key Laboratory of Molecular Neuroscience

12. The Hong Kong University of Science & Technology

13. Kowloon

Abstract

A fast responsive and two photon fluorescent probe (HCyNAc) for carboxylesterase (CaE) has been designed and used for the two-photon imaging of the endogenous CaE level in living HeLa cells under 800 nm NIR excitation.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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