Injectable biomaterial induces regeneration of the intervertebral disc in a caprine loaded disc culture model-Reference-Cited by-同舟云学术

Injectable biomaterial induces regeneration of the intervertebral disc in a caprine loaded disc culture model

Published:2023 Issue:13 Volume:11 Page:4630-4643
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Snuggs Joseph W.¹²^ORCID,Emanuel Kaj S.³⁴^ORCID,Rustenburg Christine³^ORCID,Janani Ronak⁵^ORCID,Partridge Simon⁵,Sammon Christopher⁵^ORCID,Smit Theo H.³,Le Maitre Christine L.¹²^ORCID

Affiliation:

1. Department of Oncology and Metabolism, Medical School, The University of Sheffield, Sheffield, UK

2. Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK

3. Amsterdam UMC, University of Amsterdam, Department of Orthopedic Surgery and Sports Medicine, Amsterdam Movement Sciences, Amsterdam, the Netherlands

4. Department of Orthopedic Surgery, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Center+, Maastricht, the Netherlands

5. Materials Engineering Research Institute, Sheffield Hallam University, Sheffield, UK

Abstract

Here, the efficacy of an injectable hydrogel system (NPgel), either alone or together with progenitor cells, was investigated within a degenerate loaded disc model. NPgel inhibited cellular catabolism and promoted anabolism, supporting regeneration.

Funder

Medical Research Council

Versus Arthritis

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D3BM00150D

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