Design, synthesis and biological evaluation of valepotriate derivatives as novel antitumor agents-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of valepotriate derivatives as novel antitumor agents

Published:2017 Issue:51 Volume:7 Page:31899-31906
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Bo¹²³⁴⁵,Guo Ruiying⁶¹⁷⁴⁵,Hu Yongzhou⁶¹⁷⁴⁵,Dong Xiaowu⁶¹⁷⁴⁵^ORCID,Lin Nengming⁸⁹¹⁰¹¹⁵,Dai Xiaoyang¹²³⁴⁵,Wu Honghai¹²³⁴⁵,Ma Shenglin⁸⁹¹⁰¹¹⁵,Yang Bo¹²³⁴⁵

Affiliation:

1. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research

2. Institute of Pharmacology and Toxicology

3. School of Pharmaceutical Sciences

4. Zhejiang University

5. Hangzhou

6. ZJU-ENS Joint Laboratory of Medicinal Chemistry

7. College of Pharmaceutical Sciences

8. Translational Medicine Research Center

9. Nanjing Medical University

10. Affiliated Hangzhou Hospital

11. Hangzhou First People's Hospital

Abstract

A series of valepotriate derivatives with novel skeleton were synthesized from commercial available genipin. Among them, 1e exhibited significant anti-proliferation activity against H1975 cells by inducing mitochondrion-mediated apoptosis.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA27478A

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