Deprotective Lossen rearrangement: a direct and general transformation of Nms-amides to unsymmetrical ureas-Reference-Cited by-同舟云学术

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Deprotective Lossen rearrangement: a direct and general transformation of Nms-amides to unsymmetrical ureas

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Spieß Philipp¹^ORCID,Brześkiewicz Jakub¹^ORCID,Maulide Nuno¹^ORCID

Affiliation:

1. Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria

Abstract

Herein, we report the development of a deprotective functionalisation reaction that allows for the synthesis of unsymmetrical ureas through a Lossen-type rearrangement of Nms-protected amines.

Funder

Austrian Science Fund

Universität Wien

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC04974H

Reference27 articles.

1. The Death of Vitalism and The Birth of Organic Chemistry: Wohler's Urea Synthesis and the Disciplinary Identity of Organic Chemistry

2. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

3. A small molecule–kinase interaction map for clinical kinase inhibitors

4. SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

5. Potential role of sorafenib in the treatment of acute myeloid leukemia

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