Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19

Author:

Khanal Pukar12345ORCID,Dey Yadu Nandan6785,Patil Rajesh910115ORCID,Chikhale Rupesh12131415,Wanjari Manish M.16175,Gurav Shailendra S.181920215ORCID,Patil B. M.12345,Srivastava Bhavana16175,Gaidhani Sudesh N.22235

Affiliation:

1. Department of Pharmacology and Toxicology

2. KLE College of Pharmacy Belagavi

3. KLE Academy of Higher Education and Research (KAHER)

4. Belagavi-590010

5. India

6. School of Pharmaceutical Technology

7. Adamas University

8. Kolkata-700126

9. Sinhgad Technical Education Society's

10. Smt. Kashibai Navale College of Pharmacy

11. Pune

12. School of Pharmacy

13. University of East Anglia

14. Norwich

15. UK

16. Regional Ayurveda Research Institute for Drug Development

17. Gwalior-474009

18. Department of Pharmacognosy

19. Goa College of Pharmacy

20. Goa University

21. Panjim

22. Central Council for Research in Ayurvedic Sciences

23. New Delhi-110058

Abstract

The present study aimed to investigate the binding affinity of andrographolide and its derivative i.e. 14-deoxy-11,12-didehydroandrographolide with targets related to COVID-19 and their probable role in regulating multiple pathways in COVID-19 infection.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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