Mechanistic insights and importance of hydrophobicity in cationic polymers for cancer therapy-Reference-Cited by-同舟云学术

Mechanistic insights and importance of hydrophobicity in cationic polymers for cancer therapy

Published:2023 Issue:7 Volume:11 Page:1456-1468
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Kumar Nishant¹,Oqmhula Kenji²^ORCID,Hongo Kenta³^ORCID,Takagi Kengo⁴,Yusa Shin-ichi⁴^ORCID,Rajan Robin¹^ORCID,Matsumura Kazuaki¹^ORCID

Affiliation:

1. School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan

2. School of Information Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan

3. Research Center for Advanced Computing Infrastructure, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan

4. Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan

Abstract

We describe the synthesis of anticancer polymers containing hydrophobic groups. Cationic homopolymer does not show any anticancer activity on its own; however, the insertion of hydrophobic moieties synergistically enhances their anticancer activity.

Funder

Japan Society for the Promotion of Science

Mitani Foundation for Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2023/TB/D2TB02059A

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