Development and validation of an HPLC-DAD method for the quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene in human plasma and mouse matrices-Reference-Cited by-同舟云学术

Development and validation of an HPLC-DAD method for the quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene in human plasma and mouse matrices

Published:2024 Issue:14 Volume:149 Page:3815-3827
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Carona Andreia¹²,Bicker Joana¹²,Fonseca Carla¹²,da Graça Campos Maria³⁴,Falcão Amílcar¹²,Fortuna Ana¹²^ORCID

Affiliation:

1. Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

2. CIBIT/ICNAS – Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal

3. Observatory of Herb-Drug Interactions, Faculty of Pharmacy, University of Coimbra Coimbra, Portugal

4. Coimbra Chemistry Centre (CQC, FCT Unit 313) (FCTUC), Univ Coimbra, Rua Larga, Coimbra, Portugal

Abstract

This HPLC-DAD method allows a selective, accurate and precise quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene. It demonstrated to be applicable to pre-clinical studies and therapeutic drug monitoring of cannabidiol.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D4AN00070F

Reference30 articles.

1. Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview

2. Phytocannabinoids: Origins and Biosynthesis

3. A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential

4. Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over, three-arm, proof-of-concept trial

5. Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma