Tunable protein crystal size distribution via continuous slug-flow crystallization with spatially varying temperature-Reference-Cited by-同舟云学术

Tunable protein crystal size distribution via continuous slug-flow crystallization with spatially varying temperature

Published:2021 Issue:37 Volume:23 Page:6495-6505
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Mozdzierz Nicholas J.¹,Hong Moo Sun¹^ORCID,Lee Yongkyu¹²,Benisch Moritz H. P.¹³,Jiang Mo⁴^ORCID,Myerson Allan S.¹^ORCID,Braatz Richard D.¹^ORCID

Affiliation:

1. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

2. School of Chemical & Biological Engineering, Seoul National University, Seoul, South Korea

3. Institute for Chemical & Bioengineering, ETH Zurich, Zurich, Switzerland

4. Department of Chemical & Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA

Abstract

Under appropriate buffer and pH conditions, the magnitude and dispersion of the product protein crystals were reproducibly manipulated by controlling the spatial temperature along the tube in a continuous tubular crystallizer.

Funder

Bill and Melinda Gates Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CE/D1CE00387A

Reference30 articles.

1. Technology trends in antibody purification

2. Continuous downstream processing of biopharmaceuticals

3. White Paper on Continuous Bioprocessing May 20–21 2014 Continuous Manufacturing Symposium

4. Industrialization of mAb production technology: The bioprocessing industry at a crossroads

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enhanced sustainability with crystallization in continuous flow;Current Opinion in Green and Sustainable Chemistry;2024-08

2. Vaccine process technology—A decade of progress;Biotechnology and Bioengineering;2024-05-06

3. Recent Advancements in Continuous Crystallization of Proteins;Crystal Research and Technology;2023-09-27

4. The role of mixing and surface hydrophobicity on the operation of a continuous tubular slug flow crystalliser for lysozyme;Chemical Engineering Journal;2023-09

5. Narrow size distribution of lysozyme crystals in a reverse vapor diffusion set-up;CrystEngComm;2023