Synthesis, characterisation and influence of lipophilicity on cellular accumulation and cytotoxicity of unconventional platinum(iv) prodrugs as potent anticancer agents-Reference-Cited by-同舟云学术

Synthesis, characterisation and influence of lipophilicity on cellular accumulation and cytotoxicity of unconventional platinum(iv) prodrugs as potent anticancer agents

Published:2019 Issue:46 Volume:48 Page:17228-17240
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Deo Krishant M.¹²³⁴^ORCID,Sakoff Jennette⁵⁴^ORCID,Gilbert Jayne⁵⁴,Zhang Yingjie⁶⁴^ORCID,Aldrich Wright Janice R.¹²³⁴^ORCID

Affiliation:

1. Nanoscale Organisation and Dynamics Group

2. Western Sydney University

3. Campbelltown

4. Australia

5. Calvary Mater Newcastle

6. Australian Nuclear Science and Technology Organisation

Abstract

Unconventional lipophilic Pt(iv) complexes exhibited enhanced cellular accumulation compared to their hydrophilic Pt(iv) precursors, however no clear correlation was observed between increasing lipophilicity, cellular accumulation and cytotoxicity.

Funder

University of Western Sydney

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT04049H

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