Steady-state monitoring of oxygen in a high-throughput organ-on-chip platform enables rapid and non-invasive assessment of drug-induced nephrotoxicity-Reference-Cited by-同舟云学术

Steady-state monitoring of oxygen in a high-throughput organ-on-chip platform enables rapid and non-invasive assessment of drug-induced nephrotoxicity

Published:2023 Issue:14 Volume:148 Page:3204-3216
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Kann Samuel H.¹²,Shaughnessey Erin M.¹³,Zhang Xin²^ORCID,Charest Joseph L.⁴,Vedula Else M.⁴^ORCID

Affiliation:

1. Draper Scholar, 555 Technology Square, Cambridge, MA 02139, USA

2. Department of Mechanical Engineering, Boston University, 110 Cummington Mall, Boston, MA 02215, USA

3. Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA

4. Draper, 555 Technology Square, Cambridge, MA 02139, USA

Abstract

Measurement of steady-state oxygen levels in a high-throughput organ-on-chip platform enabled rapid and non-invasive monitoring of dose and time-dependent injury responses of human kidney cells to cisplatin, a drug with toxic effects in the kidney.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AN/D3AN00380A

Reference61 articles.

1. Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

2. Latest Trends in Biosensing for Microphysiological Organs-on-a-Chip and Body-on-a-Chip Systems

3. Time course of cisplatin-induced nephrotoxicity and hepatotoxicity

4. Discovery of Potential Biomarkers with Dose- and Time-Dependence in Cisplatin-Induced Nephrotoxicity Using Metabolomics Integrated with a Principal Component-Based Area Calculation Strategy

5. High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows

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