Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity-Reference-Cited by-同舟云学术

Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Mathenjwa Gciniwe S.¹²,Chakraborty Abir³^ORCID,Chakraborty Abantika³,Muller Ronel²,Akerman Mathew P.²^ORCID,Bode Moira L.⁴^ORCID,Edkins Adrienne L.³,Veale Clinton G. L.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa

2. School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville, 3209, South Africa

3. The Biomedical Biotechnology Research Unit (BioBRU), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, 6139, South Africa

4. Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, 2050, Johannesburg, South Africa

Abstract

Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.

Funder

Royal Society

University of CapeTown

South African Agency for Science and Technology Advancement

Rhodes University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00501E

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