Deformability-induced lift force in spiral microchannels for cell separation-Reference-Cited by-同舟云学术

Deformability-induced lift force in spiral microchannels for cell separation

Published:2020 Issue:3 Volume:20 Page:614-625
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Guzniczak Ewa¹²³⁴⁵^ORCID,Otto Oliver⁶⁷⁸⁹,Whyte Graeme¹²³⁴⁵,Willoughby Nicholas¹²³⁴⁵,Jimenez Melanie¹⁰¹¹¹²¹³,Bridle Helen¹²³⁴⁵^ORCID

Affiliation:

1. Heriot-Watt University

2. School of Engineering and Physical Science

3. Department of Biological Chemistry, Biophysics and Bioengineering Edinburgh Campus

4. Edinburgh

5. UK

6. Centre for Innovation Competence–Humoral Immune Reactions in Cardiovascular Diseases

7. University of Greifswald

8. 17489 Greifswald

9. Germany

10. Biomedical Engineering Division

11. James Watt School of Engineering

12. University of Glasgow

13. G12 8LT UK

Abstract

We introduce a novel combination of deformability-induced lift force (F_D) and secondary Dean flow in spiral microchannel translated into a label-free purification approach applicable to mammalian cells, processing of millions of cells per min, up to high purities and recovery.

Funder

Royal Society of Edinburgh

Bundesministerium für Bildung und Forschung

Deutsches Zentrum für Herz-Kreislaufforschung

Engineering and Physical Sciences Research Council

Royal Academy of Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/C9LC01000A