Copper oxide nanoparticles induce cuproptosis and ferroptosis through mitochondrial concatenation-Reference-Cited by-同舟云学术

Copper oxide nanoparticles induce cuproptosis and ferroptosis through mitochondrial concatenation

Published:2024 Issue: Volume: Page:
ISSN:2051-8153
Container-title:Environmental Science: Nano
language:en
Short-container-title:Environ. Sci.: Nano

Author:

Jiang Muran¹,Tao Xiaoqi¹²,Pang Yingxin¹,Qin Zongmin¹,Song Erqun³^ORCID,Song Yang⁴^ORCID

Affiliation:

1. Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Food Science, Southwest University, 2 Tiansheng Rd, Beibei District, Chongqing, 400715, China

2. Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, 2 Tiansheng Rd, Beibei District, Chongqing, 400715, China

3. Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng Rd, Beibei District, Chongqing, 400715, China

4. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Rd, Haidian District, Beijing, 100085, China

Abstract

Our work suggested that cuproptosis serves as a key toxic mechanism of CuO NPs, damaging mitochondria to induce ferroptosis by disrupting mitochondrial membrane lipid synthesis.

Funder

National Natural Science Foundation of China

Science Fund for Distinguished Young Scholars of Chongqing Municipality

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/EN/D4EN00455H

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4. A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging

5. CC Chemokine Receptor 2-Targeting Copper Nanoparticles for Positron Emission Tomography-Guided Delivery of Gemcitabine for Pancreatic Ductal Adenocarcinoma