New insights into the disulfide bond formation enzymes in epidithiodiketopiperazine alkaloids-Reference-Cited by-同舟云学术

New insights into the disulfide bond formation enzymes in epidithiodiketopiperazine alkaloids

Published:2021 Issue:11 Volume:12 Page:4132-4138
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Huan¹²³⁴⁵,Fan Jie¹²³⁴⁵^ORCID,Zhang Peng¹²³⁴⁵,Hu Youcai⁶⁷⁸⁹¹⁰^ORCID,Liu Xingzhong¹²³⁴⁵,Li Shu-Ming¹¹¹²¹³¹⁴¹⁵^ORCID,Yin Wen-Bing¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Mycology

2. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering

3. Institute of Microbiology

4. Chinese Academy of Sciences

5. Beijing 100101

6. State Key Laboratory of Bioactive Substance and Function of Natural Medicines

7. Institute of Materia Medica

8. Chinese Academy of Medical Sciences

9. Peking Union Medical College

10. Beijing 100050

11. Institut für Pharmazeutische Biologie und Biotechnologie

12. Fachbereich Pharmazie

13. Philipps-Universität Marburg

14. Marburg 35037

15. Germany

Abstract

A FAD-dependent oxidoreductase TdaR was responsible for α, β-disulfide formation in the biosynthesis of pretrichodermamide A. TdaR, together with its homologs AclT and GliT, catalysed not only α, α- but also α, β-disulfide formation in fungi.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Deutsche Forschungsgemeinschaft

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC06647H

Reference50 articles.

1. The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis

2. Epidithiodioxopiperazines. occurrence, synthesis and biogenesis

3. Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism

4. Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures, and Biological Activities

5. Biosynthesis and function of gliotoxin in Aspergillus fumigatus

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells;Translational Oncology;2024-11

2. Reconstitution of the Early Stage of Chetomin Biosynthesis in Aspergillus fumigatus Leads to the Production of Epipolythiodioxopiperazines;Organic Letters;2024-05-20

3. Chemistry meets biology in the coordination dynamics of metalloproteins;Journal of Inorganic Biochemistry;2024-02

4. Formation of Bridged Disulfide in Epidithiodioxopiperazines;ChemBioChem;2024-01-04

5. Lecanicilliums A–F, Thiodiketopiperazine-Class Alkaloids from a Mangrove Sediment-Derived Fungus Lecanicillium kalimantanense;Marine Drugs;2023-10-31