Mechanistic insights into EGFR membrane clustering revealed by super-resolution imaging-Reference-Cited by-同舟云学术

Mechanistic insights into EGFR membrane clustering revealed by super-resolution imaging

Published:2015 Issue:6 Volume:7 Page:2511-2519
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Gao Jing¹²³⁴⁵,Wang Ye⁶⁷⁸³⁹,Cai Mingjun¹²³⁴,Pan Yangang¹²³⁴⁵,Xu Haijiao¹²³⁴,Jiang Junguang¹²³⁴,Ji Hongbin⁶⁷⁸³⁹,Wang Hongda¹²³⁴

Affiliation:

1. State Key Laboratory of Electroanalytical Chemistry

2. Changchun Institute of Applied Chemistry

3. Chinese Academy of Sciences

4. Changchun, P.R. China

5. Graduate University of Chinese Academy of Sciences

6. State Key laboratory of Cell Biology

7. Institute of Biochemistry and Cell Biology

8. Shanghai Institutes for Biological Sciences

9. Shanghai 200031, P.R. China

Abstract

We investigate the distribution of membrane EGFR by direct stochastic optical reconstruction microscopy (dSTORM). Our results illustrate the clustering distribution pattern of EGFR in polarized cells and uncover the essential role of lipid rafts in EGFR cluster maintenance.

Funder

Ministry of Science and Technology

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NR/C4NR04962D

Reference50 articles.

1. Functional rafts in cell membranes

2. Revisiting the Fluid Mosaic Model of Membranes