Functionalised staple linkages for modulating the cellular activity of stapled peptides-Reference-Cited by-同舟云学术

Functionalised staple linkages for modulating the cellular activity of stapled peptides

Published:2014 Issue:5 Volume:5 Page:1804-1809
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Lau Yu Heng¹²³,de Andrade Peterson¹²³,Quah Soo-Tng⁴⁵,Rossmann Maxim⁶²⁷,Laraia Luca¹²³⁸⁹,Sköld Niklas¹²³,Sum Tze Jing¹²³,Rowling Pamela J. E.¹⁰²¹¹,Joseph Thomas L.¹²¹³,Verma Chandra¹²¹³¹⁴¹⁵¹⁶,Hyvönen Marko⁶²⁷,Itzhaki Laura S.¹⁰²¹¹,Venkitaraman Ashok R.⁸⁹¹⁷,Brown Christopher J.⁴⁵,Lane David P.⁴⁵,Spring David R.¹²³

Affiliation:

1. University Chemical Laboratory

2. University of Cambridge

3. Cambridge CB2 1EW, UK

4. p53 Laboratory (A*STAR)

5. , Singapore 138648

6. Department of Biochemistry

7. Cambridge CB2 1GA, UK

8. MRC Cancer Unit

9. Hutchison/MRC Research Centre

10. Department of Pharmacology

11. Cambridge CB2 1PD, UK

12. Bioinformatics Institute (A*STAR)

13. , Singapore 138671

14. Department of Biological Sciences

15. National University of Singapore (NUS)

16. Singapore 117543

17. Cambridge CB2 0XZ, UK

Abstract

A divergent synthetic strategy for generating helical p53 peptides bearing functionalised staple linkages, allowing for efficient optimisation of cellular activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC00045E

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