Preparation of viromimetic rod-like nanoparticle vaccines (RLNVax) and study of their humoral immune activation efficacy

Author:

Huang Zichao12,Zhu Zhenyi12,Liu Liping12,Song Wantong123ORCID,Chen Xuesi123ORCID

Affiliation:

1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China

3. Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, China

Abstract

Antigen proteins were modified onto the surfaces of nanoparticles with various shapes. This study investigates the effect of structural anisotropy on the efficacy of humoral immune activation by nanoparticle vaccines.

Funder

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

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