Beyond the limiting gap length: peripheral nerve regeneration through implantable nerve guidance conduits

Author:

Redolfi Riva Eugenio12ORCID,Özkan Melis34ORCID,Contreras Estefania56,Pawar Sujeet3,Zinno Ciro12,Escarda-Castro Enrique7ORCID,Kim Jaehyeon7ORCID,Wieringa Paul7ORCID,Stellacci Francesco38,Micera Silvestro124,Navarro Xavier6910ORCID

Affiliation:

1. The Biorobotic Institute, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy

2. Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy

3. Institute of Materials, école Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland

4. Bertarelli Foundation Chair in Translational Neural Engineering, Center for Neuroprosthetics and Institute of Bioengineering, école Polytechnique Federale de Lausanne, Lausanne, Switzerland

5. Integral Service for Laboratory Animals (SIAL), Faculty of Veterinary, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain

6. Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain

7. Complex Tissue Regeneration Department, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands

8. Institute of Materials, Department of Bioengineering and Global Health Institute, École Polytechnique Fédérale de Lausanne (EPFL), Station 12, CH-1015 Lausanne, Switzerland

9. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain

10. Institute Guttmann Foundation, Hospital of Neurorehabilitation, Badalona, Spain

Abstract

This review provides a critical overview of implantable guidance conduits for nerve regeneration and the challenges in improving their performance in limiting gap lesions to establish them as an alternative to autografts in clinical practice.

Funder

Horizon 2020 Framework Programme

Instituto de Salud Carlos III

European Commission

Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro

Fondation Bertarelli

Publisher

Royal Society of Chemistry (RSC)

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