Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain-Reference-Cited by-同舟云学术

Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain

Author:

Chaikuad Apirat¹²³⁴⁵,Petros Andrew M.⁶⁷⁸,Fedorov Oleg¹⁹³¹⁰⁵,Xu Jing⁶⁷⁸,Knapp Stefan¹²³⁴⁵

Affiliation:

1. Nuffield Department of Clinical Medicine

2. SGC

3. University of Oxford

4. Oxford OX3 7DQ

5. UK

6. Abvvie

7. North Chicago

8. USA

9. Target Discovery Institute

10. Oxford OX3 7FZ

Abstract

Fragments for the development of ATAD2 bromodomain inhibitors have been identified and characterized by NMR and co-crystallization.

Funder

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

Reference31 articles.

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