A polymer network architecture provides superior cushioning and lubrication of soft tissue compared to a linear architecture

Author:

Cooper Benjamin G.12ORCID,DeMoya Christian D.23ORCID,Sikes Katie J.4,Frisbie David D.4,Phillips Nikki4,Nelson Brad B.4,McIlwraith C. Wayne4,Kawcak Chris E.4,Goodrich Laurie R.4,Snyder Brian D.25,Grinstaff Mark W.13ORCID

Affiliation:

1. Department of Chemistry, Boston University, Boston, MA, 02215, USA

2. Center for Advanced Orthopedic Studies (CAOS), Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA

3. Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA

4. Gail Holmes Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA

5. Department of Orthopedic Surgery, Boston Childrens Hospital, Boston, MA, 02215, USA

Abstract

We report the relationships between linear vs. network polymer architecture and biomechanical outcomes including lubrication and cushioning when the polymers are applied to the surface of articulating knee cartilage.

Funder

Boston University

Harvard Catalyst

Wallace H. Coulter Foundation

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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