Self-diffusion of a highly concentrated monoclonal antibody by fluorescence correlation spectroscopy: insight into protein–protein interactions and self-association-Reference-Cited by-同舟云学术

Self-diffusion of a highly concentrated monoclonal antibody by fluorescence correlation spectroscopy: insight into protein–protein interactions and self-association

Published:2019 Issue:33 Volume:15 Page:6660-6676
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Hung Jessica J.¹²³⁴^ORCID,Zeno Wade F.⁵²³⁴,Chowdhury Amjad A.¹²³⁴^ORCID,Dear Barton J.¹²³⁴,Ramachandran Kishan¹²³⁴,Nieto Maria P.¹²³⁴,Shay Tony Y.¹²³⁴,Karouta Carl A.¹²³⁴,Hayden Carl C.⁵²³⁴,Cheung Jason K.⁶⁷⁸⁹⁴,Truskett Thomas M.¹²³⁴¹⁰^ORCID,Stachowiak Jeanne C.⁵²³⁴¹¹^ORCID,Johnston Keith P.¹²³⁴

Affiliation:

1. McKetta Department of Chemical Engineering

2. The University of Texas at Austin

3. Austin

4. USA

5. Department of Biomedical Engineering

6. Pharmaceutical Sciences

7. MRL

8. Merck & Co., Inc.

9. Rahway

10. Department of Physics

11. Institute for Molecular and Cellular Biology

Abstract

Measurement and interpretation of self-diffusion of a highly concentrated mAb with different formulations in context of viscosity and protein self-interactions.

Funder

Merck Sharp and Dohme

Welch Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SM/C9SM01071H

Reference121 articles.

1. Factors Affecting the Viscosity in High Concentration Solutions of Different Monoclonal Antibodies