Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di-<i>N</i>-oxide derivatives as potential antitubercular agents-Reference-Cited by-同舟云学术

Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential antitubercular agents

Published:2024 Issue:8 Volume:15 Page:2785-2791
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

González-González Alonzo¹^ORCID,Sánchez-Sánchez Oscar¹^ORCID,Wan Baojie²,Franzblau Scott²^ORCID,Palos Isidro³^ORCID,Espinoza-Hicks José C.⁴^ORCID,Moreno-Rodríguez Adriana⁵^ORCID,Martínez-Vázquez Ana Verónica¹^ORCID,Lara-Ramírez Edgar E.¹^ORCID,Ortiz-Pérez Eyra¹^ORCID,Paz-González Alma D.¹^ORCID,Rivera Gildardo¹^ORCID

Affiliation:

1. Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Mexico

2. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, USA

3. Unidad Académica Multidisciplinaria Reynosa-Rodhe, Universidad Autónoma de Tamaulipas, Mexico

4. Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Mexico

5. Laboratorio de Estudios Epidemiológicos, Clínicos, Diseños Experimentales e Investigación, Facultad de Ciencias Químicas, Universidad Autónoma “Benito Juárez” de Oaxaca, Mexico

Abstract

n-, and isobutyl esters of quinoxaline-1,4-di-N-oxide are effective anti-tuberculosis agents against replicating and non-replicating H37Rv bacilli, with top ten lead compounds being relatively safe with selectivity index values over 70.

Funder

Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00221K

Reference31 articles.

1. The history of tuberculosis

2. Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines

3. Synthesis, 3D-QSAR analysis and biological evaluation of quinoxaline 1,4-di-N-oxide derivatives as antituberculosis agents

4. Tuberculosis