Alkene carboamination/oxidative denitrogenation of 3-allyl-3-hydrazinylindolin-2-ones: one-pot entry to spirocyclopropyloxindoles-Reference-Cited by-同舟云学术

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Alkene carboamination/oxidative denitrogenation of 3-allyl-3-hydrazinylindolin-2-ones: one-pot entry to spirocyclopropyloxindoles

Published:2024 Issue:10 Volume:22 Page:2124-2136
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Manenti Marco¹^ORCID,Villa Tommaso¹^ORCID,Macetti Giovanni¹^ORCID,Silvani Alessandra¹^ORCID

Affiliation:

1. Department of Chemistry, University of Milan, via C. Golgi 19, Milano, 20133, Italy

Abstract

A mild one-pot protocol has been developed for the synthesis of diversely substituted spirocyclopropyloxindoles, in yields up to 73% and with diastereoselectivity close to 1 : 1.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D3OB02115G

Reference42 articles.

1. Syntheses and Applications of Spirocyclopropyl Oxindoles: A Decade Review

2. Cyclopropane Derivatives and their Diverse Biological Activities

3. The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

4. Combined Scaffold Evaluation and Systems‐Level Transcriptome‐Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes

5. Design and Synthesis of DNA-Interactive β-Carboline-Oxindole Hybrids as Cytotoxic and Apoptosis-Inducing Agents

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