Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity-Reference-Cited by-同舟云学术

Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity

Published:2015 Issue:7 Volume:13 Page:2001-2011
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Furse Samuel¹²³⁴⁵^ORCID,Mak LokHang⁵²³⁴⁶,Tate Edward W.¹²³⁴⁵,Templer Richard H.¹²³⁴⁵,Ces Oscar¹²³⁴⁵,Woscholski Rüdiger¹²³⁴⁵,Gaffney Piers R. J.¹²³⁴⁵

Affiliation:

1. Institute of Chemical Biology

2. Imperial College London

3. London SW7 2AZ

4. UK

5. Department of Chemistry

6. Division of Molecular Biology

Abstract

Single enantiomers of PI-4-P, with a range ofsn-2-fatty acid esters, were prepared efficiently. The effects of the degree ofsn-2-unsaturation on the kinetic parameters ofSopB were determined.

Funder

Medical Research Council

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02258K

Reference48 articles.

1. Phosphoinositide metabolism and insulin secretion from isolated rat pancreatic islets.

2. Inositide-Dependent Phospholipase C Signaling Mimics Insulin in Skeletal Muscle Differentiation by Affecting Specific Regions of the Cyclin D3 Promoter

3. Phosphoinositides in cell regulation and membrane dynamics

4. Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission

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