Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect-Reference-Cited by-同舟云学术

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Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect

Published:2021 Issue:12 Volume:19 Page:2753-2766
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sevrain Charlotte M.¹²³⁴⁵,Fontaine Delphine⁶⁷⁸⁵,Bauduin Alicia¹²³⁴⁵,Guéguinou Maxime⁶⁷⁸⁵,Zhang Bei Li⁶⁹¹⁰¹¹¹²,Chantôme Aurélie⁶⁷⁸⁵,Mahéo Karine⁶⁷⁸⁵,Pasqualin Côme⁶⁹¹⁰¹¹¹²,Maupoil Véronique⁶⁹¹⁰¹¹¹²,Couthon Hélène¹²³⁴⁵,Vandier Christophe⁶⁷⁸⁵,Jaffrès Paul-Alain¹²³⁴⁵^ORCID

Affiliation:

1. Univ. Brest

2. CNRS

3. CEMCA UMR 6521

4. Brest

5. France

6. Univ. Tours

7. INSERM

8. 37000 Tours

9. Laboratoire STIM EA 7349

10. and Groupe Physiologie des Cellules Cardiaques et Vasculaires

11. Faculté de Pharmacie

12. 37200 Tours

Abstract

Sulfur analogues of Ohmline feature activation properties of SK3 ion channels. One compound exhibits promising endothelium dependent vasorelaxation.

Funder

Centre National de la Recherche Scientifique

Institut National de la Santé et de la Recherche Médicale

Université de Bretagne Occidentale

Université François-Rabelais

Conseil Régional du Centre-Val de Loire

Région Bretagne

Institut National Du Cancer

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00021G

Reference61 articles.

1. Structure of potassium channels

2. Contribution of small conductance K+channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+/Ca2+exchange knockout mice

3. Small conductance Ca 2+ -activated K + channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases

4. Targeting SKCa Channels in Cancer: Potential New Therapeutic Approaches

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