Catalyst- and solvent-free regiospecific SNHAr phosphinylation of pyridines with H-phosphinates mediated by benzoylphenylacetylene-Reference-Cited by-同舟云学术

Catalyst- and solvent-free regiospecific S_N^HAr phosphinylation of pyridines with H-phosphinates mediated by benzoylphenylacetylene

Published:2024 Issue:26 Volume:22 Page:5419-5427
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Khrapova Kseniya O.¹,Volkov Pavel A.¹,Telezhkin Anton A.¹,Albanov Alexander I.¹^ORCID,Chupakhin Oleg N.²^ORCID,Trofimov Boris A.¹^ORCID

Affiliation:

1. A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk 664033, Russian Federation

2. I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 S. Kovalevskoi/Akademicheskaya St., Ekaterinburg 620219, Russian Federation

Abstract

Pyridines undergo a facile SNHAr phosphinylation with H-phosphinates under catalyst- and solvent-free conditions (50–55 °C) in the presence of benzoylphenylacetylene to afford 4-phosphinylpyridines in up to 68% yield.

Funder

Ministry of Education and Science of the Russian Federation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00661E

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