Two approaches for the synthesis of levo-praziquantel-Reference-Cited by-同舟云学术

Two approaches for the synthesis of levo-praziquantel

Published:2021 Issue:20 Volume:19 Page:4507-4514
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Shou Haowen¹²³⁴⁵,He Zhaoting⁶⁷⁸,Peng Gang⁹⁷¹⁰⁸,Su Weike¹²³⁴⁵^ORCID,Yu Jingbo¹²³⁴⁵^ORCID

Affiliation:

1. National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients

2. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals

3. Zhejiang University of Technology

4. Hangzhou 310014

5. PR China

6. Beijing Fukangren Bio-pharm Tech Co.

7. Ltd

8. P. R. China

9. Huadong Medicine Co.

10. Hangzhou 310011

Abstract

Two pathways for the preparation of levo-praziquantel are herein reported, which involves mechanochemical (asymmetric) aza-Henry/acylation reaction, hydrogenation reaction, (chiral resolution) and solvent-free acylation-ring closing reaction.

Funder

Science and Technology Program of Zhejiang Province

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00453K

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