Identification of the effect of N-glycan modification and its sialylation on proteolytic stability and glucose-stabilizing activity of glucagon-like peptide 1 by site-directed enzymatic glycosylation

Author:

Liu Huan1,Liang Zengwei1,Wang Yu1,Li Yingze1,Wang Ya1,Guo Xin23,Guan Wanyi4ORCID,Zou Wei1,Wu Zhigang1ORCID

Affiliation:

1. College of Food and Biology, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, China

2. Research Center, Hebei Province Hospital of Chinese Medicine, Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Shijiazhuang, Hebei 050011, China

3. Department of Pathology and Laboratory Medicine, Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan

4. Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Key Laboratory of Molecular and Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei 050024, China

Abstract

Site-directed glycosylation of glucagon-like peptide 1 enhanced its proteolytic stability and improved its blood glucose-stabilizing activity.

Funder

Natural Science Foundation of Hebei Province

Hebei Provincial Department of Human Resources and Social Security

Youth Foundation of Hebei Educational Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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