Identification of the effect of <i>N</i>-glycan modification and its sialylation on proteolytic stability and glucose-stabilizing activity of glucagon-like peptide 1 by site-directed enzymatic glycosylation-Reference-Cited by-同舟云学术

Identification of the effect of N-glycan modification and its sialylation on proteolytic stability and glucose-stabilizing activity of glucagon-like peptide 1 by site-directed enzymatic glycosylation

Published:2022 Issue:49 Volume:12 Page:31892-31899
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liu Huan¹,Liang Zengwei¹,Wang Yu¹,Li Yingze¹,Wang Ya¹,Guo Xin²³,Guan Wanyi⁴^ORCID,Zou Wei¹,Wu Zhigang¹^ORCID

Affiliation:

1. College of Food and Biology, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, China

2. Research Center, Hebei Province Hospital of Chinese Medicine, Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Shijiazhuang, Hebei 050011, China

3. Department of Pathology and Laboratory Medicine, Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan

4. Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Key Laboratory of Molecular and Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei 050024, China

Abstract

Site-directed glycosylation of glucagon-like peptide 1 enhanced its proteolytic stability and improved its blood glucose-stabilizing activity.

Funder

Natural Science Foundation of Hebei Province

Hebei Provincial Department of Human Resources and Social Security

Youth Foundation of Hebei Educational Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA05872C