Advances in identification and validation of protein targets of natural products without chemical modification-Reference-Cited by-同舟云学术

Advances in identification and validation of protein targets of natural products without chemical modification

Published:2016 Issue:5 Volume:33 Page:719-730
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Chang J.¹²³⁴⁵,Kim Y.¹²³⁴⁵,Kwon H. J.¹²³⁴⁵

Affiliation:

1. Department of Biotechnology

2. Translational Research Center for Protein Function Control

3. College of Life Science & Biotechnology

4. Yonsei University

5. Seoul 120-749

Abstract

This review focuses on and reports case studies of the latest advances in target protein identification methods for label-free natural products. The integration of newly developed technologies will provide new insights and highlight the value of natural products for use as biological probes and new drug candidates.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00107B

Reference108 articles.

1. Selective enzyme purification by affinity chromatography.

2. Target identification and mechanism of action in chemical biology and drug discovery

3. Identification and validation of protein targets of bioactive small molecules

4. Proteomic methods for drug target discovery

5. Method for Quantitative Protein−Ligand Affinity Measurements in Compound Mixtures

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