Real-time monitoring of granule properties during high shear wet granulation by near-infrared spectroscopy with a chemometrics approach

Author:

Shikata F.12345,Kimura S.12345,Hattori Y.678910,Otsuka M.678910ORCID

Affiliation:

1. Formulation Research

2. PST CFU

3. Medicine Development Centre

4. Eisai Co., Ltd.

5. Gifu 501-6195

6. Research Institute of Pharmaceutical Sciences

7. Faculty of Pharmacy

8. Musashino University

9. Tokyo 202-8585

10. Japan

Abstract

An in-line near-infrared spectroscopy monitoring method was developed for analyzing granule properties during a high shear wet granulation process.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference37 articles.

1. U.S. Department of Health and Human Services, Food and Drug Administration, Centre for Drug Evaluation and Research. 2004. Guidance for industry, PAT-a framework for innovative pharmaceutical development, manufacturing, and quality assurance, http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070305.pdf

2. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH harmonized tripartite guideline, Pharmaceutical development Q8(R2), 2009

3. A quality by design approach to scale-up of high-shear wet granulation process

4. Rheology, granule growth and granule strength: Application to the wet granulation of lactose–MCC mixtures

5. Process control and scale-up of pharmaceutical wet granulation processes: a review

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