Pterostilbene alleviated cerebral ischemia/reperfusion-induced blood–brain barrier dysfunction <i>via</i> inhibiting early endothelial cytoskeleton reorganization and late basement membrane degradation-Reference-Cited by-同舟云学术

Pterostilbene alleviated cerebral ischemia/reperfusion-induced blood–brain barrier dysfunction via inhibiting early endothelial cytoskeleton reorganization and late basement membrane degradation

Published:2023 Issue:18 Volume:14 Page:8291-8308
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yang Zhi-hong¹,Liu Ye-ju¹,Ban Wei-kang¹^ORCID,Liu Hai-bo¹,Lv Ling-juan¹,Zhang Bao-yue²,Liu Ai-lin²,Hou Zi-yu¹,Lu Juan¹,Chen Xi¹,You Yu-yang³

Affiliation:

1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China

2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

3. Beijing Institute of Technology, Beijing 100081, China

Abstract

Pterostilbene inhibits the cytoskeleton reorganization of hBMECs by regulating actin polymerization in the early stage and inhibits the degradation of BM by activating Wnt pathway and inhibiting MMP-9 in the late stage, jointly protecting BBB.

Funder

Beijing Municipal Natural Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO02639F

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