Cell recognition based on features extracted by AFM and parameter optimization classifiers

Author:

Wang Junxi1234,Yang Fan1234,Wang Bowei1234,Hu Jing123,Liu Mengnan123,Wang Xia1234,Dong Jianjun1234,Song Guicai4,Wang Zuobin12345ORCID

Affiliation:

1. International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China

2. Centre for Opto/Bio-Nano Measurement and Manufacturing, Zhongshan Institute of Changchun University of Science and Technology, Zhongshan 528400, China

3. Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China

4. College of Physics, Changchun University of Science and Technology, Changchun 130022, China

5. JR3CN & IRAC, University of Bedfordshire, Luton LU1 3JU, UK

Abstract

This study employed an atomic force microscope (AFM) to characterize the morphological and mechanical properties of four cell lines. Then a cell recognition method based on machine learning and feature engineering was proposed.

Funder

Natural Science Foundation of Jilin Province

National Key Research and Development Program of China

National Natural Science Foundation of China

HORIZON EUROPE Framework Programme

Department of Science and Technology of Jilin Province

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

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