Design of potent tyrosinase inhibiting <i>N</i>-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies-Reference-Cited by-同舟云学术

Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies

Published:2024 Issue:23 Volume:14 Page:16546-16559
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Khan Farhan Mahmood¹,Abbasi Muhammad Athar¹^ORCID,Rehman Aziz-ur¹,Siddiqui Sabahat Zahra¹,Sadiq Butt Abdul Rehman¹,Raza Hussain²^ORCID,Hassan Mubashir³,Ali Shah Syed Adnan⁴⁵,Shahid Muhammad⁶,Kim Song Ja²^ORCID

Affiliation:

1. Department of Chemistry, Government College University, Lahore, 54000, Pakistan

2. Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, 32588, South Korea

3. The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, Ohio, 43205, USA

4. Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Selangor, 42300, Malaysia

5. Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Selangor, 42300, Malaysia

6. Department of Biochemistry, University of Agriculture, Faisalabad, 38040, Pakistan

Abstract

By using a convergent methodology, a unique series of N-arylated 4-yl-benzamides containing a bi-heterocyclic thiazole-triazole core was synthesized and the structures of these hybrid molecules, 9a–k, were corroborated through spectral analyses.

Funder

Higher Education Commission, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01063A

Reference47 articles.

1. Synthesis of heterocyclic compounds via Michael and Hantzsch reactions

2. Novel 1,2,4-triazole analogues as mushroom tyrosinase inhibitors: synthesis, kinetic mechanism, cytotoxicity and computational studies

3. Aromaticity as a Cornerstone of Heterocyclic Chemistry

4. Synthesis and DNA binding of novel bioactive thiazole derivatives pendent to N-phenylmorpholine moiety