Novel sulfonamide derivatives as multitarget antidiabetic agents: design, synthesis, and biological evaluation

Author:

Ayoup Mohammed Salah12ORCID,Khaled Nourhan1,Abdel-Hamid Hamida1,Ghareeb Doaa A.3,Nasr Samah A.3,Omer Ahmed45,Sonousi Amr67,Kassab Asmaa E.6ORCID,Eltaweil Abdelazeem S.18

Affiliation:

1. Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt

2. Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia

3. Bio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt

4. Polymer Institute of the Slovak Academy of Sciences, Dúbravská Cesta 9 845 41, Bratislava, Slovakia

5. Polymer Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Alexandria 21934, Egypt

6. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562 Kasr El-Aini Street, Cairo, Egypt

7. University of Hertfordshire hosted by Global Academic Foundation, New Administrative Capital, Cairo, Egypt

8. Department of Engineering, Faculty of Technology and Engineering, University of Technology and Applied Sciences, Sultanate of Oman

Abstract

A series of new sulfonamide derivatives connected through an imine linker to five or seven membered heterocycles were designed and synthesized.

Funder

Academy of Scientific Research and Technology

Publisher

Royal Society of Chemistry (RSC)

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