Synthesis of functionalized tetrahydropyridazines via catalyst-free self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes-Reference-Cited by-同舟云学术

Synthesis of functionalized tetrahydropyridazines via catalyst-free self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes

Published:2016 Issue:66 Volume:6 Page:61680-61685
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Zhimin¹²³⁴⁵,Zhang Li¹²³⁴⁵,Chen Qingqing¹²³⁴⁵,Lu Tao¹²³⁴⁵,Zhou Qingfa¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Natural Medicines

2. Department of Organic Chemistry

3. China Pharmaceutical University

4. Nanjing

5. P. R. China

Abstract

An efficient method for the synthesis of structurally diverse functionalized tetrahydropyridazines via self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes was developed, which may play an important role in drug discovery.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA13985J

Reference38 articles.

1. Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis

2. Heterocyclic Compounds as Inflammation Inhibitors

3. Recent Advances in the Research of Heterocyclic Compounds as Antitubercular Agents

4. Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advances in the synthesis of functionalized tetrahydropyridazines from hydrazones;Organic & Biomolecular Chemistry;2024

2. Michael addition of P-nucleophiles to azoalkenes provides simple access to phosphine oxides bearing an alkylhydrazone moiety;Frontiers in Chemistry;2023-04-13

3. Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds;ACS Omega;2022-11-01

4. FeCl 3 ‐Catalyzed Formal [3+2] Cyclodimerization of 4‐Carbonyl‐1,2‐diaza‐1,3‐dienes;European Journal of Organic Chemistry;2021-10

5. Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones;Tetrahedron Letters;2021-10