Insights into tumor size-dependent nanoparticle accumulation using deformed organosilica nanoprobes

Author:

Miao Yuchen1,Du Hengda1,Zhang Wenqing1,Yang Dongliang2ORCID,Tang Kaiyuan1,Fang Qiang134,Zhang Junjie15ORCID

Affiliation:

1. School of Fundamental Sciences, Bengbu Medical University, Bengbu, Anhui Province 233030, China

2. Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211816, China

3. Department of Microbiology and Parasitology, Bengbu Medical University, Bengbu, Anhui Province 233030, China

4. Anhui Key Laboratory of Infection and Immunity, Bengbu Medical University, Bengbu, Anhui Province 233030, China

5. State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China

Abstract

Deformed organosilica nanoprobes (CDPF) exhibit enhanced accumulation within larger tumors, highlighting the pivotal role of the tumor microenvironment in the optimization of nanoparticle-based therapeutic strategies.

Funder

Anhui Provincial Department of Education

National College Students Innovation and Entrepreneurship Training Program

Publisher

Royal Society of Chemistry (RSC)

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