Delivery of anti-cancer and anti-depression doxepin drug by nickel oxide nanoparticles originated from the Cressa nudicaulis plant extract

Author:

Lu Yan1,Han Mingru2,Esmaeili Shahri Effat3,Abbaspour Sedighe4,Tayebee Reza4ORCID

Affiliation:

1. Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, No. 440 Jiyan Road, Jinan 250117, Shandong, China

2. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China

3. Department of Chemistry, Payame Noor University (PNU), Tehran, Iran

4. Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar, 96179-76487, Iran

Abstract

Cressa nudicaulis is used to prepare NiO NPs. The prepared nanoparticles were approved for doxepin loading. The drug release properties were also investigated at pH 6.5 and 37 °C. An MTT experiment was performed on the human hepatocellular carcinoma cell line Huh-7.

Funder

Hakim Sabzevari University

Iran National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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