Synthesis of α-chiral amides via synergistic visible-light-induced Wolff rearrangement and asymmetric NHC catalysis

Author:

Wang Jiaomei1,Chen Yangxu2,Miao Siyan2,Yao Changsheng2ORCID,Zhang Kai2ORCID

Affiliation:

1. School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou 221018, P. R. China

2. Jiangsu Key Lab of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, Jiangsu 221116, P. R. China

Abstract

Herein, a visible-light-induced chiral N-heterocyclic carbene (NHC) catalyzed asymmetric amination of ketenes has been developed. This strategy provides a facile synthetic protocol for the efficient construction of α-chiral amides.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Xuzhou Institute of Technology

Publisher

Royal Society of Chemistry (RSC)

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