Ligand's electronegativity controls the sense of enantioselectivity in BIFOP-X palladium-catalyzed allylic alkylations
Author:
Affiliation:
1. Department of Chemistry
2. University of Cologne
3. Organic Chemistry
4. 50939 Cologne
5. Germany
Abstract
Palladium-catalyzed allylic alkylations of Na(CH(CO2Me)2 with 1,3-diphenylallyl acetate, employing BIFOP-X (X = H, D, Cl, CN, N3) ligands, yield the C–C coupling product (up to 91% yield, 70% ee). A NBO effect reveals a change of stereochemistry.
Funder
Deutsche Forschungsgemeinschaft
BASF
Bayer
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C9NJ02798J
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5. Enantioselective Allylic Substitution of Cyclic Substrates by Catalysis with Palladium Complexes of P,N-Chelate Ligands with a Cymantrene Unit
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