Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry

Author:

Lizzul-Jurse Antoine12345,Bailly Laetitia12345,Hubert-Roux Marie12345,Afonso Carlos12345ORCID,Renard Pierre-Yves12345,Sabot Cyrille12345

Affiliation:

1. Normandie Univ

2. COBRA

3. UMR 6014 & FR 3038

4. Univ Rouen-Normandie

5. INSA Rouen

Abstract

A family of readily functionalizable phosphonium-tagged fluorescent coumarins is reported. Their utility was illustrated through the preparation of a FRET-based protease-sensitive probe which exhibited increased electrospray ionization efficiency.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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