Facile access to 4′-(<i>N</i>-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap <i>N</i>7-guanine-methyltransferase nsp14-Reference-Cited by-同舟云学术

Facile access to 4′-(N-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14

Published:2022 Issue:38 Volume:20 Page:7582-7586
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Amador Romain¹^ORCID,Delpal Adrien²^ORCID,Canard Bruno²^ORCID,Vasseur Jean-Jacques¹^ORCID,Decroly Etienne²^ORCID,Debart Françoise¹^ORCID,Clavé Guillaume¹^ORCID,Smietana Michael¹^ORCID

Affiliation:

1. Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 1919 route de Mende, 34095 Montpellier, France

2. Architecture et Fonction des Macromolécules Biologiques, Université d'Aix-Marseille, CNRS, 163 Avenue de Luminy, Marseille, France

Abstract

4′-(N-Acylsulfonamide) adenosine derivatives have been efficiently synthetized via the sulfo-click reaction and their biological activity has been evaluated as potential inhibitors of the SARS-CoV-2 RNA cap N7-guanine- methyltransferase nsp14.

Funder

Agence Nationale de la Recherche

H2020 European Institute of Innovation and Technology

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01569B

Reference38 articles.

1. Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists