Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma-Reference-Cited by-同舟云学术

Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma

Published:2022 Issue:23 Volume:13 Page:6813-6829
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Modrzycka Sylwia¹,Kołt Sonia¹,Polderdijk Stéphanie G. I.²,Adams Ty E.²,Potoczek Stanisław³,Huntington James A.²,Kasperkiewicz Paulina¹^ORCID,Drąg Marcin¹^ORCID

Affiliation:

1. Department of Chemical Biology and Bioimaging, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

2. Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, UK

3. Department of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wrocław Medical University, Pasteura 1, 50-367 Wrocław, Poland

Abstract

Using a collection of natural and unnatural amino acids, we synthesized a set of fluorescent activity-based probes for the fast, direct, and simultaneous detection of coagulation factors in human plasma.

Funder

Fundacja na rzecz Nauki Polskiej

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01108E

Reference71 articles.

1. Role of the Extrinsic Pathway of Blood Coagulation in Hemostasis and Thrombosis

2. Intrinsic Pathway of Coagulation and Thrombosis