Oxalic acid as a dual C1 surrogate for heterogeneous palladium-catalyzed tandem four-component quinazolinone synthesis

Abstract

A Pd-catalyzed four-component dual carbonylative approach for cascade synthesis of 2-aryl quinazolinones has been developed with ammonium carbamate as an ammonia precursor and oxalic acid as a bifunctional reagent acting as CO and C-atom surrogate.