Concise total synthesis of opioids-Reference-Cited by-同舟云学术

Concise total synthesis of opioids

Published:2022 Issue:9 Volume:9 Page:2322-2327
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

He Huan¹,Xue Fanglin¹,Hu Zhao¹,Li Peng¹,Xiao Qian¹,Zhang Maojie¹,Xue Fei¹,Zhang Dan¹,Song Hao¹,Liu Xiao-Yu¹,Zheng Zhibing²,Li Song²,Zhong Wu²,Qin Yong¹^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan Province, China

2. National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China

Abstract

A concise total synthesis of opioids is presented. The development of a regioselective Pd-catalyzed dearomatization arene coupling that requires no additional blocking groups allows for efficient access to a common thebaine core.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00202G

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