Ruthenium(ii) polypyridyl complexes as dual inhibitors of telomerase and topoisomerase-Reference-Cited by-同舟云学术

Ruthenium(ii) polypyridyl complexes as dual inhibitors of telomerase and topoisomerase

Published:2015 Issue:34 Volume:44 Page:15145-15156
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Liao Guoliang¹²³⁴⁵,Chen Xiang¹²³⁴⁵,Wu Jingheng¹²³⁴⁵,Qian Chen¹²³⁴⁵,Wang Yi¹²³⁴⁵,Ji Liangnian¹²³⁴⁵,Chao Hui¹²³⁴⁵

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry

2. School of Chemistry and Chemical Engineering

3. Sun Yat-Sen University

4. Guangzhou 510275

5. P. R. China

Abstract

Three ruthenium(ii) polypyridyl complexes, [Ru(bpy)₂(icip)]²⁺ (1), [Ru(bpy)₂(pdppz)]²⁺ (2), and [Ru(bpy)₂(tactp)]²⁺ (3), were selected to inhibit telomerase by inducing and stabilising the G-quadruplex structure, and behave as topoisomerase I/II poisons at the same time.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT03585B

Reference69 articles.

1. Telomerase and the maintenance of chromosome ends

2. Telosome, a Mammalian Telomere-associated Complex Formed by Multiple Telomeric Proteins

3. Telomere states and cell fates

4. Shelterin: the protein complex that shapes and safeguards human telomeres

5. The application of DNA and RNA G-quadruplexes to therapeutic medicines

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