Caged polycyclic polyprenylated acylphloroglucinols as Cav3.2 low voltage-gated Ca2+ channel inhibitors from Hypericum curvisepalum-Reference-Cited by-同舟云学术

Caged polycyclic polyprenylated acylphloroglucinols as Ca_v3.2 low voltage-gated Ca²⁺ channel inhibitors from Hypericum curvisepalum

Published:2022 Issue:94 Volume:58 Page:13135-13138
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ye Yan-Song¹^ORCID,Liu Rui¹²,Jiang Na-Na¹³,Li Song-Yu¹,Nian Yin¹^ORCID,Xu Gang¹^ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China

2. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, China

3. University of Chinese Academy of Sciences, Beijing, 100049, China

Abstract

Caged PPAPs including an unprecedented octahydro-2,5-methanoindene skeleton were discovered as potent Cav3.2 T-type Ca2+ channel inhibitors.

Funder

Natural Science Foundation of Yunnan Province

Yunan Ten Thousand Talents Plan Young and Elite Talents Project

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC05396A

Reference24 articles.

1. Polycyclic Polyprenylated Acylphloroglucinols

2. Research Progress of Polycyclic Polyprenylated Acylphloroglucinols

3. Plukenetione A. An unusual adamantyl ketone from Clusia plukenetii (guttiferae)

4. Polycyclic compounds: Ideal drug scaffolds for the design of multiple mechanism drugs?

5. Diamonds are a Chemist's Best Friend: Diamondoid Chemistry Beyond Adamantane

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