Darzens reaction of thioisatins and sulfonium salts: approach to the synthesis of thiochromenone derivatives with anticancer potency

Author:

Shen Jinhui12345,Yang Yang675,Hou Xiaoli12345,Zeng Wenlei12345,Yu Aimin12345,Zhao Xiaowei12345,Meng Xiangtai12345ORCID

Affiliation:

1. Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion

2. School of Chemistry & Chemical Engineering

3. Tianjin University of Technology

4. Tianjin 300384

5. P. R. China

6. Guilin Medical University

7. Guilin 541004

Abstract

A new Darzens reaction of thioisatins and sulfonium salts has, for the first time, been reported. Some of the synthesized thiochromenone derivatives have been found to show good potent anticancer activities against six different cancer cell lines.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin City

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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