Orally administered octacosanol improves liver insulin resistance in high-fat diet-fed mice through the reconstruction of the gut microbiota structure and inhibition of the TLR4/NF-κB inflammatory pathway-Reference-Cited by-同舟云学术

Orally administered octacosanol improves liver insulin resistance in high-fat diet-fed mice through the reconstruction of the gut microbiota structure and inhibition of the TLR4/NF-κB inflammatory pathway

Published:2023 Issue:2 Volume:14 Page:769-786
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Ding Yin-Yi¹²^ORCID,Fang Yumeng¹,Pan Yuxiang¹,Lan Jinchi¹,Xu Tao³,Zhang Wanyue¹,Mao Huijuan⁴,Gu Zhenyu¹,Chen Xi⁵,Shen Qing¹⁶

Affiliation:

1. Food Nutrition Science Center, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China

2. Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China

3. Huzhou Shengtao Biotechnology LLC, Huzhou, 313000, China

4. Hangzhou Linping Hospital of Traditional Chinese Medicine, Linping, Zhejiang, 311106, China

5. Center for General Practice Medicine, Department of General Practice Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 310014, China

6. Collaborative Innovation Center of Seafood Deep Processing, Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China, 310018

Abstract

1-Octacosanol improves liver insulin resistance in HFD-fed mice through the reconstruction of the gut microbiota structure and inhibition of the TLR4/NF-κB inflammatory pathway.

Funder

Natural Science Foundation of Zhejiang Province

Medical Science and Technology Project of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO02463B

Reference71 articles.

1. Prognostic Value of Insulin Resistance Assessed by HOMA-IR in Non-Diabetic Patients with Decompensated Heart Failure

2. Brain insulin resistance as a mechanistic mediator links peripheral metabolic disorders with declining cognition