Development of novel PP2A activators for use in the treatment of acute myeloid leukaemia-Reference-Cited by-同舟云学术

Development of novel PP2A activators for use in the treatment of acute myeloid leukaemia

Published:2016 Issue:20 Volume:14 Page:4605-4616
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Toop Hamish D.¹²³⁴^ORCID,Dun Matthew D.⁵⁶⁷⁴⁸,Ross Bryony K.⁹¹⁰⁴,Flanagan Hayley M.⁵⁶⁷⁴⁸,Verrills Nicole M.⁵⁶⁷⁴⁸,Morris Jonathan C.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. UNSW Australia

3. Sydney

4. Australia

5. School of Biomedical Sciences and Pharmacy

6. The University of Newcastle

7. Callaghan

8. Hunter Medical Research Institute

9. Calvary Mater Hospital

10. Newcastle

Abstract

The synthesis and biological evaluation of new cytotoxic analogs of AAL(S) are reported. Our findings identify key structural motifs required for anti-cancer effects.

Funder

Cancer Institute NSW

Cancer Council NSW

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00556J

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