Observing enzyme ternary transition state analogue complexes by 19F NMR spectroscopy-Reference-Cited by-同舟云学术

Observing enzyme ternary transition state analogue complexes by 19F NMR spectroscopy

Published:2017 Issue:12 Volume:8 Page:8427-8434
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ampaw Anna¹²³⁴,Carroll Madison¹²³⁴,von Velsen Jill⁵⁶⁷⁸,Bhattasali Debabrata⁹²³⁴,Cohen Alejandro¹⁰¹¹²³⁴,Bowler Matthew W.⁵⁶⁷⁸^ORCID,Jakeman David L.¹²³⁴⁹^ORCID

Affiliation:

1. Department of Chemistry

2. Dalhousie University

3. Halifax

4. Canada B3H 4R2

5. European Molecular Biology Laboratory

6. Grenoble Outstation

7. CS 90181 F-38042 Grenoble

8. France

9. College of Pharmacy

10. Proteomics and Mass Spectrometry Core Facility

11. Life Sciences Research Institute

Abstract

Ternary transition state analogue (TSA) complexes probing the isomerization of β-d-glucose 1-phosphate (G1P) into d-glucose 6-phosphate (G6P) catalyzed by catalytically active, fluorinated (5-fluorotryptophan), β-phosphoglucomutase (βPGM) have been observed directly by ¹⁹F NMR spectroscopy.

Funder

Natural Sciences and Engineering Research Council of Canada

Institute of Infection and Immunity

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC04204C

Reference39 articles.

1. Why did Nature select phosphate for its dominant roles in biology?

2. Metal Fluorides as Analogues for Studies on Phosphoryl Transfer Enzymes

3. Evolution of enzyme superfamilies

4. Caught in the Act: The Structure of Phosphorylated β-Phosphoglucomutase from Lactococcus lactis,

5. The Pentacovalent Phosphorus Intermediate of a Phosphoryl Transfer Reaction

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